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mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Mitotane is a solid inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for doable dosage changes.As a result of long-acting metabolite, not thought of a drug of decision in the elderly; connected to fal
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